Endocrine Abstracts

Justification and objectives: Gestational Diabetes Mellitus (GDM) is associated with an increased risk of Pregnancy-Induced Hypertension (PIH). Previous studies suggest a relationship between inflammatory markers and the development of PIH and obstetric and perinatal complications. The aim of the study was to establish the relationship between pro and anti-inflammatory cytokines and the development of PIH and the impact on obstetric and perinatal outcomes.<p clas...

Obesity is a major health problem commonly associated with severe comorbidities, including insulin resistance and type 2 diabetes mellitus (T2DM). Emerging evidence suggests that production and secretion of certain micro RNAs (miRNAs) are dysregulated under adverse metabolic conditions and might exert a key role in the development and progression of different metabolic-related pathologies. However, the alteration of the plasma miRNA profile under obesity condition and its path...

Development and progression of liver diseases, from non-alcoholic fatty liver disease (NAFLD) to steatohepatitis (NASH), and hepatocellular carcinoma (HCC), seem to be accompanied by a dysregulation of the expression of alternative splicing variants (SVs) and appearance of aberrant SVs. The splicing factor 3B subunit 1 (SF3B1) represents a crucial player for the functional assembly of the spliceosome, the core machinery that controls the splicing process, and its activity can ...